| Pair Name | Celastrol, Afatinib | ||
| Phytochemical Name | Celastrol (PubChem CID: 122724 ) | ||
| Anticancer drug Name | Afatinib (PubChem CID: 10184653 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Celastrol, Afatinib | |||
| Disease Info | [ICD-11: 2C25] | Lung cancer | Investigative | |
| Biological Phenomena | Induction-->Paraptosis | |||
| In Vitro Model | NCI-H23 | Lung adenocarcinoma | Homo sapiens (Human) | CVCL_1547 |
| NCI-H292 | Lung mucoepidermoid carcinoma | Homo sapiens (Human) | CVCL_0455 | |
| Result | These findings suggest that the depletion of intracellular glutathione by quercetin and sulforaphane could strengthen the anti-cancer efficacy of oxaliplatin. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Celastrol acts synergistically with afatinib to suppress non-small cell lung cancer cell proliferation by inducing paraptosis. J Cell Physiol. 2021 Jun;236(6):4538-4554. doi: 10.1002/jcp.30172. | Click |
